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X-WR-CALDESC:Events for Chair of Scientific Culture of the University of the Basque Country
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DTSTART:20170326T010000
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DTSTART:20171029T010000
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DTSTART;TZID=Europe/Madrid:20170113T130000
DTEND;TZID=Europe/Madrid:20170113T140000
DTSTAMP:20260407T060327
CREATED:20231106T152830Z
LAST-MODIFIED:20231106T152830Z
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SUMMARY:Achucarro Seminars: A conserved role for Mlc1 in regulating the surface localization of Glialcam from fish to humans
DESCRIPTION:Xehetasunak \n\n\n\n\nData eta ordua:  \n\n\n\n\n\n\n\n\n\nEgoitza \n\n\n\n\n\n\n\n\nResearcher: Alejandro Barrallo (University of Barcelona) \n\n\n\nAbstract: Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a leukodystrophy characterized by myelin vacuolization and caused by mutations in MLC1 or GLIALCAM. Patients with recessive mutations in either MLC1 or GLIALCAM show the same clinical phenotype. It has been shown that GLIALCAM is necessary for the correct targeting of MLC1 to the membrane at cell junctions\, but its own localization was independent of MLC1 in vitro. However\, recent studies in Mlc1 ko mice have shown that GlialCAM is mislocalized in glial cells. In order to investigate whether the relationship between Mlc1 and GlialCAM is species-specific\, we first identified MLC-related genes in zebrafish and generated an mlc1 ko zebrafish. We have characterized mlc1 ko zebrafish both functionally and histologically and compared the phenotype with that of the Mlc1 ko mice. In mlc1 ko zebrafish\, as in Mlc1 ko mice\, Glialcam is mislocalized. Re-examination of a brain biopsy from an MLC patient indicates that GLIALCAM is also mislocalized in Bergmann glia in the cerebellum. In vitro\, impaired localization of GlialCAM was observed in astrocyte cultures from Mlc1 ko mouse only in the presence of elevated potassium levels\, which mimics neuronal activity. In summary\, here we demonstrate an evolutionary conserved role for MLC1 in regulating glial surface levels of GLIALCAM\, and this interrelationship explains why patients with mutations in either gene (MLC1 or GLIALCAM) share the same clinical phenotype.
URL:https://katedra.eus/en/events/achucarro-seminars-a-conserved-role-for-mlc1-in-regulating-the-surface-localization-of-glialcam-from-fish-to-humans/
LOCATION:Achucarro Basque Center for Neuroscience\, Bizkaia Science and Technology Park Building 205\, Zamudio
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DTSTART;TZID=Europe/Madrid:20170117T190000
DTEND;TZID=Europe/Madrid:20170117T200000
DTSTAMP:20260407T060327
CREATED:20231106T152547Z
LAST-MODIFIED:20231106T152624Z
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SUMMARY:The amazing learning capacity of machines
DESCRIPTION:Xehetasunak \n\n\n\n\nData eta ordua:  \n\n\n\n\n\n\n\n\n\nEgoitza \n\n\n\n\n\n\n\n\nWe have been investigating how to create intelligent machines for many years. Researchers in the 1950s and 60s wanted to program machines by hand\, coding the knowledge of human beings and enabling them to have logical reasoning abilities. During that time they observed that machines’ intelligence was very rigid and was far from being as flexible as human intelligence\, and this flexibility is what our world requires. This is not where the current artificial intelligence revolution comes from. In the end we have understood that machines have to learn by themselves in order for their intelligence to be comparable to ours. In this talk we will find out how machines learn and what they are already able to do. \n\n\n\nGorka Azkune\, researcher at the University of Deusto\, will be giving a talk on this topic: “The amazing learning capacity of machines”. The talk will take place on 17 January at Azkuna Zentroa in Bilbao. It will be in Basque and is part of the Zientziateka programme. \n\n\n\nZientziateka is a monthly initiative organised by the Chair of Scientific Culture of the University of the Basque Country UPV/EHU and Azkuna Zentroa to raise awareness of current scientific matters. \n\n\n\nTickets should be collected from the Azkuna Zentroa Information Point. Entry is free.
URL:https://katedra.eus/en/events/the-amazing-learning-capacity-of-machines/
LOCATION:Azkuna Zentroa\, Plaza Arriquibar\, 4\, Bilbao
ATTACH;FMTTYPE=image/jpeg:https://katedra.eus/app/uploads/2016/12/gorka_rrss.jpg
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